The synchronicity of cardiac myocardial function is important for maintaining cardiac output. Diseased hearts often develop dyssynchrony that, in turn, worsens the performance of an already impaired ventricle. Conventional measurements of dyssynchrony are based on the relative timing of absolute peak values of strain and strain rate, assessed using echocardiography. These methods do not account for the shape and progression of strain changes that occur over the course of the cardiac cycle.
We have developed a new measurement of cardiac dyssynchrony based on inner-vector angles of strain changes occurring over the whole cardiac cycle. Details regarding the methods and scientific background for this approach can be found in Regional Cardiac Dysfunction and Dyssynchrony in a Murine Model of Afterload Stress - Michael Bauer, Susan Cheng, Kazumasa Unno, Soeun Ngoy, Fen-Chiung Lin, Ronglih Liao [PLoS ONE 8(4): e59915.]
We have released our software based algorithm used to calculate the novel measurement of cardiac dyssynchrony as Free and Open Source Software. This software currently supports data exports from Visualsonic and TomTec strain software packages.Download
If you use the software in research please cite:
Michael Bauer, Susan Cheng, Kazumasa Unno, Soeun Ngoy, Fen-Chiung Lin, Ronglih Liao; Regional Cardiac Dysfunction and Dyssynchrony in a Murine Model of Afterload Stress. ; PLoS ONE 8(4): e59915.
Please use the following instructions to use the program:
guiin the directory and doubleclick to run it
Save as...button to select a file to save the results
Goto run the analysis